2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-130907
    Fmoc-N-PEG24-acid 2170484-59-8 99.91%
    Fmoc-N-PEG24-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fmoc-N-PEG24-acid
  • HY-W074901
    tert-Butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate 381722-48-1 99.92%
    tert-Butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate is a PROTAC linker that can be used in the synthesis of PROTACs.
    tert-Butyl 4-(piperazin-1-ylmethyl)piperidine-1-carboxylate
  • HY-130324
    Azido-PEG7-amine 1333154-77-0 99.93%
    Azido-PEG7-amine is a non-cleavable 7 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG7-amine is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG7-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG7-amine
  • HY-140830
    m-PEG12-azide 2170098-29-8 98.6%
    m-PEG12-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG12-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG12-azide
  • HY-128833
    Bis-NH2-PEG2 929-59-9 99.82%
    Bis-NH2-PEG2 (PROTAC Linker 19) is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Bis-NH2-PEG2
  • HY-W006524
    H2N-PEG2-CH2COOH 134978-97-5 99.87%
    H2N-PEG2-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    H2N-PEG2-CH2COOH
  • HY-34415
    4-Bromobutanoic acid tert-butyl ester 110661-91-1 99.73%
    4-Bromobutanoic acid tert-butyl ester (tert-Butyl 4-Bromobutyrate) is a PROTAC linker that can be used in the synthesis of PROTACs.
    4-Bromobutanoic acid tert-butyl ester
  • HY-W008296
    NH2-C6-NH-Boc 51857-17-1 99.77%
    NH2-C6-NH-Boc is a PROTAC linker which refers to the alkyl/ether composition. NH2-C6-NH-Boc can be used in the synthesis the Mcl-1 inhibitor based on PROTAC.
    NH2-C6-NH-Boc
  • HY-30755
    7-Boc-(2,7-Diazaspiro[3.5]nonane) 896464-16-7 99.82%
    7-Boc-(2,7-Diazaspiro[3.5]nonane) is a PROTAC linker that can be used in the synthesis of PROTACs.
    7-Boc-(2,7-Diazaspiro[3.5]nonane)
  • HY-140215
    Azido-PEG6-amine 957486-82-7
    Azido-PEG6-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG6-amine is also a non-cleavable 6 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG6-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG6-amine
  • HY-133399
    Alkyne-PEG4-maleimide 1609651-90-2 98.44%
    Alkyne-PEG4-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Alkyne-PEG4-maleimide is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Alkyne-PEG4-maleimide
  • HY-Y0786
    1,3-Dibromo-5,5-dimethylhydantoin 77-48-5 99.20%
    1,3-Dibromo-5,5-dimethylhydantoin is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs.
    1,3-Dibromo-5,5-dimethylhydantoin
  • HY-42569
    Methyl 3-hydroxypropanoate 6149-41-3 99.83%
    Methyl 3-hydroxypropanoate is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs.
    Methyl 3-hydroxypropanoate
  • HY-130211
    Azido-PEG5-alcohol 86770-68-5
    Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG5-alcohol
  • HY-33366
    Boc-NH-PEG3-CH2COOH 462100-06-7 99.60%
    Boc-NH-PEG3-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTAC.
    Boc-NH-PEG3-CH2COOH
  • HY-W008279
    Amino-PEG2-NH-Boc 127828-22-2 98.0%
    Amino-PEG2-NH-Boc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Amino-PEG2-NH-Boc
  • HY-Y1139
    Pimelic acid 111-16-0 ≥98.0%
    Pimelic acid (Heptanedioic acid; 1,5-Pentanedicarboxylic acid) is a seven-carbon α,ω-dicarboxylic acid and a downstream product of fatty acid synthesis. Pimelic acid is a key precursor in biotin biosynthesis. Pimelic acid can be converted to pimelic acid-CoA by the BioW enzyme, thereby bypassing exogenous biotin requirements to support growth in various biotinytrophic bacteria and fungi, and reversing antibiotic-induced inhibition of biotin synthesis. Furthermore, Pimelic acid has been proposed as a highly specific biomarker for oxygen-induced retinopathy in mice. Pimelic acid can be used to study retinopathy of preterm infants, oxygen-induced retinopathy, and microbial biotin metabolism.
    Pimelic acid
  • HY-135804
    NH2-PEG3-C2-Boc 252881-74-6
    NH2-PEG3-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    NH2-PEG3-C2-Boc
  • HY-Y0148
    10-Hydroxydecanoic acid 1679-53-4 99.77%
    10-Hydroxydecanoic acid (10-HDAA) is a saturated fatty acid derived from 10-hydroxy-trans-2-decenoic acid, which can be isolated from royal jelly. 10-Hydroxydecanoic acid exhibits various biological activities, including anti-inflammatory, insecticidal, anti-malarial, and anti-Leishmania properties, as well as enhancing antigen-specific immune responses. The anti-inflammatory effects of 10-Hydroxydecanoic acid are primarily mediated by inhibiting the activation of NF-κB and the translation of interferon regulatory factor 1 (IRF-1), which reduces the production of interleukin 6 (IL-6) and nitric oxide (NO) in inflammatory cells. Additionally, 10-Hydroxydecanoic acid alleviates neuroinflammatory responses through the p53-autophagy pathway and the p53-NLRP3 pathway. Finally, 10-Hydroxydecanoic acid enhances antigen-specific immune responses by promoting the effective uptake of antigens by microfold cells.
    10-Hydroxydecanoic acid
  • HY-W015943
    Hex-5-yn-1-ol 928-90-5 99.82%
    Hex-5-yn-1-ol (5-Hexyn-1-ol) is a PROTAC linker that can be used in the synthesis of PROTACs.
    Hex-5-yn-1-ol
PROTAC Linkers Isoform Comparison

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